Celecoxib vs. Diclofenac

Celecoxib vs Diclofenac

Comparison of two major prescription NSAIDs in the USA: Celecoxib (Celebrex) and Diclofenac (Voltaren).

FeatureCelecoxibDiclofenac
SelectivityCOX-2 SelectiveNon-Selective
GI RiskLowHigh

Safety for the Stomach and Heart

Celecoxib was designed in the USA to reduce ulcer risk. It targets COX-2 specifically, leaving protective stomach enzymes alone. Celecoxib was designed in the USA to reduce ulcer risk. It targets COX-2 specifically, leaving protective stomach enzymes alone. Celecoxib was designed in the USA to reduce ulcer risk. It targets COX-2 specifically, leaving protective stomach enzymes alone. Celecoxib was designed in the USA to reduce ulcer risk. It targets COX-2 specifically, leaving protective stomach enzymes alone.

Clinical Use in American Clinics

Diclofenac is often paired with misoprostol to mitigate GI risk, but Celecoxib remains the primary choice for those with sensitive stomachs. Diclofenac is often paired with misoprostol to mitigate GI risk, but Celecoxib remains the primary choice for those with sensitive stomachs. Diclofenac is often paired with misoprostol to mitigate GI risk, but Celecoxib remains the primary choice for those with sensitive stomachs.