Oxycodone vs. Hydrocodone

Oxycodone vs Hydrocodone

A clinical comparison of the two most prescribed semi-synthetic opioids in the USA (Schedule II).

FeatureOxycodoneHydrocodone
Potency1.5x Morphine1.0x Morphine
Common HubPercocetVicodin

Pharmacological Potency Differences

Oxycodone is 50% more potent than Hydrocodone. It is used for severe recovery, while Hydrocodone is more common for moderate surgeries. Oxycodone is 50% more potent than Hydrocodone. It is used for severe recovery, while Hydrocodone is more common for moderate surgeries. Oxycodone is 50% more potent than Hydrocodone. It is used for severe recovery, while Hydrocodone is more common for moderate surgeries. Oxycodone is 50% more potent than Hydrocodone. It is used for severe recovery, while Hydrocodone is more common for moderate surgeries.

Tolerance and Side Effect Profiles

Both carry high addiction risks. Some U.S. clinical reports suggest Hydrocodone may cause slightly more itching (histamine release). Both carry high addiction risks. Some U.S. clinical reports suggest Hydrocodone may cause slightly more itching (histamine release). Both carry high addiction risks. Some U.S. clinical reports suggest Hydrocodone may cause slightly more itching (histamine release).