The Central Sensitization Model
U.S. clinical consensus describes fibromyalgia as 'central sensitization,' where the brain and spinal cord amplify pain signals. Treatments focus on calming the overactive nervous system rather than treating localized inflammation.
FDA-Approved Triple Therapy
Only three drugs are specifically FDA-indicated for fibromyalgia in the United States: Lyrica (Pregabalin), Cymbalta (Duloxetine), and Savella (Milnacipran). Most other treatments are used off-label by specialists.
Medication Options for Fibromyalgia
FDA-Approved Options
Off-Label Adjuvants
Frequently Asked Questions
Is fibromyalgia a type of arthritis?
No. Unlike arthritis, fibromyalgia does not cause joint damage or inflammation. It is a neurological pain processing disorder.
Why isn't ibuprofen helpful?
Fibromyalgia is not an inflammatory condition, so NSAIDs like ibuprofen typically provide minimal relief compared to nerve-modulating drugs.