Muscle Relaxant Directory
Clinical reference for antispasmodics and skeletal muscle relaxants used in US pain management.
Muscle relaxants are a clinical class of drugs used to treat muscle spasms and spasticity. They are generally divided into antispasmodics (for acute injuries) and antispastics (for chronic neurological conditions).
In the United States, these are primarily prescribed for lower back pain, neck strains, and recovery from musculoskeletal trauma.
Explore Muscle Relaxants

Cyclobenzaprine
High-potency antispasmodic (Flexeril) for acute musculoskeletal injury and spasms.

Methocarbamol
Low-sedation muscle relaxant (Robaxin) used alongside physical therapy protocols.

Tizanidine
Potent antispastic (Zanaflex) used for severe muscle tension and spinal cord issues.

Baclofen
GABA-derivative used for neurological spasticity and chronic muscle stiffness.

Carisoprodol
Schedule IV controlled substance (Soma) for severe, acute musculoskeletal pain.
Common Questions & Safety
Do muscle relaxants work directly on the muscle?
Most (except Dantrolene) do not. They work on the brain and spinal cord to reduce motor neuron activity, effectively 'relaxing' the CNS control over the muscle.
Can I take Flexeril with Ibuprofen?
Yes. Clinical practice often combines these to treat both the inflammatory cause and the resulting muscle spasm (multimodal therapy).
Is drowsiness common?
Yes. Drowsiness is the most common side effect. Patients should avoid driving until they know how the medication affects their alertness.